15973-38-3Relevant academic research and scientific papers
Transacetoacetylation with tert-Butyl Acetoacetate: Synthetic Apllications
Witzeman, J. Stewart,Nottingham, W. Dell
, p. 1713 - 1718 (2007/10/02)
Reaction of various nucleophiles with tert-butyl acetoacetate (t-BAA, 1a) is shown to be a convenient method for the preparation of a wide variety of acetoacetic acid derivatives.This material can be used to prepare acetoacetates and acetoacetamides from a wide variety of alcohols and amines.Reaction of 1a with an unhindered primary amine such as n-heptylamine under standard conditions gives unwanted byproducts due to the formation of the enamines 24 and 25.Formation of these byproducts can be minimized by dilution and/or altering the mode of addition.
