159730-72-0Relevant academic research and scientific papers
Phenyl substituted fused tricyclic compound and uses thereof
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Paragraph 0207; 0209; 0210, (2019/05/16)
The present invention relates to a phenyl substituted fused tricyclic compound and uses thereof, further to a pharmaceutical composition containing the compound. According to the present invention, the compound or the pharmaceutical composition can be use
Sequential Assembly of Morita-Baylis-Hillman Carbonates and Activated ortho-Vinylbenzaldehydes to Construct Chiral Methanobenzo[7]annulenone Frameworks
Jiang, Bo,Xiao, Ben-Xian,Ouyang, Qin,Liang, Hua-Ping,Du, Wei,Chen, Ying-Chun
supporting information, (2019/05/08)
The α-regioselective asymmetric [3 + 2] annulation reaction of Morita-Baylis-Hillman carbonates from isatins and activated ortho-vinylbenzaldehyses was developed by the catalysis of a chiral tertiary amine. The sequential N-heterocyclic carbene-mediated intramolecular Stetter reaction was conducted to finally furnish the bridged 5,8-methanobenzo[7]annulen-9-one architectures incorporating a spirooxindole motif with excellent stereoselectivity.
Fluoralkylphenylamidines and the use thereof as fungicides
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Page/Page column 49, (2012/11/07)
The present invention relates to fluoroalkylphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this pur
FUNGICIDAL MIXTURES OF AMIDINYLPHENYL COMPOUNDS
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Page/Page column 63, (2008/12/06)
This invention relates to fungicidal mixtures of certain phenylamidines, their N-oxides, and/or agriculturally suitable salts thereof, and to compositions comprising such mixtures and methods for using such mixtures as fungicides.
Synthesis, biological activity, and molecular modeling studies of selective 5-HT(2C/2B) receptor antagonists
Forbes, Ian T.,Dabbs, Steven,Duckworth, D. Malcolm,Ham, Peter,Jones, Graham E.,King, Frank D.,Saunders, Damian V.,Blaney, Frank E.,Naylor, Christopher B.,Baxter, Gordon S.,Blackburn, Thomas P.,Kennett, Guy A.,Wood, Martyn D.
, p. 4966 - 4977 (2007/10/03)
The synthesis and biological activity are reported for a series of analogues of the previously published indole urea 2 (SB-206553), designed to probe the 5-HT(2C) receptor binding site. Small molecule modeling studies have been used to define a region in space which is allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor. In a complementary approach, docking of 2 into our model of the 5-HT(2C) receptor has allowed us to propose a novel primary binding interaction for this series of diaryl ureas, involving a potential double hydrogen-bonding interaction between the urea carbonyl oxygen of the ligand and two serine residues in the receptor. The difference of two valine residues in the 5-HT(2C) receptor for leucine residues in the 5-HT(2A) receptor is believed to account for the observed 5- HT(2C)/5-HT(2A) selectivity with 2.
