159734-11-9

Basic information

• Product Name: (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-1-phenyl-hexan-1-one
• Synonyms: (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-1-phenyl-hexan-1-one
• CAS NO: 159734-11-9
• Molecular Weight: 348.558
• Mol File: 159734-11-9.mol

Chemical Properties

• CAS DataBase Reference: (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-1-phenyl-hexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-1-phenyl-hexan-1-one(159734-11-9)
• EPA Substance Registry System: (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-1-phenyl-hexan-1-one(159734-11-9)

Safety Data

• Hazardous Substances Data: 159734-11-9(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 159734-08-4 (S)-4-Benzyl-3-[(2S,3S)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-hexanoyl]-oxazolidin-2-one 
• 159683-81-5 4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylidenebutanal 
• 87184-99-4 4-tert-butyldimethylsilyloxybutan-1-ol 
• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 
• 100-59-4 phenylmagnesium chloride 
• 159734-10-8 (2S,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-4-methylene-hexanoic acid methoxy-methyl-amide 

Downstream Products

• 154920-01-1 (2R,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-4-methylene-1-phenyl-hexan-3-ol 
• 205864-62-6 tert-Butyl-dimethyl-[3-((4S,5S)-2,2,5-trimethyl-6-phenyl-[1,3]dioxan-4-yl)-but-3-enyloxy]-silane 
• 1027209-06-8 (-)-(1'S,2'R)-3-(1'-Benzyloxy-2'-methyl-3'-phenylpropyl)but-3-en-1-ol 
• 159813-54-4 3-((4S,5S,6S)-2,2,5-Trimethyl-6-phenyl-[1,3]dioxan-4-yl)-but-3-en-1-ol 
• 159734-12-0 3-((4S,5S,6R)-2,2,5-Trimethyl-6-phenyl-[1,3]dioxan-4-yl)-but-3-en-1-ol 

Relevant articles and documents

Towards the synthesis of the squalestatins/zaragozic acids: Synthesis of an advanced intermediate and introduction of the C-1 sidechain

A highly convergent synthesis of a squalestatin/zaragozic acid A C-4-decarboxydeoxy intermediate has been achieved. The key step involves the construction of the C-1-C-1′ bond by the addition of a fully functionalized C-1 sidechain anion (derived from iod

Synthesis of the C-1 sidechain of the squalestatins and zaragozic acid A

A synthesis of a protected C-1 side chain precursor (2) of the anti-cholesteremic agents the squalestatins and zaragozic acid A has been achieved in 9 steps from 1,4-butanediol. The key transformations involve a one pot oxidation/α-methylenation sequence