1597428-48-2

Upstream product

• 60080-98-0 (2-bromo-5-methoxyphenyl)(phenyl)methanone 
• 71-43-2 benzene 
• 17549-79-0 (2-amino-5-methoxyphenyl)(phenyl)methanone 
• 108-86-1 bromobenzene 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 

Downstream Products

• 1597428-49-3 2-(3,3-dimethylbut-1-ynyl)-5-methoxybenzophenone 
• 1597428-50-6 C₂₀H₂₂O₃ 

Relevant academic research and scientific papers

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

Lewis or Br?nsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif

We developed a facile synthetic method to access cyclopenta[b]naphthalene derivatives via the Lewis or Br?nsted acid catalysed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alcohol-tethered alkylidenecyclopropanes with indole and pyrrole derivatives. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields.

Copper-catalyzed cascade cyclization of 1,5-enynes: Via consecutive trifluoromethylazidation/diazidation and click reaction: Self-assembly of triazole fused isoindolines

Copper-catalyzed cascade cyclization of 1,5-enynes with two types of hypervalent reagents was developed via consecutive trifluoromethylazidation/diazidation and intramolecular click reaction (CUAAC), providing one-pot self-assembly of triazole fused isoindolines bearing a trifluoromethyl or an azide moiety. Moreover, the construction of a trifluoromethylcyclopropyl unit, which has been considered as a metabolically stable replacement for a tert-butyl moiety and was difficult to access, was also achieved under trifluoromethylazidation conditions. All these reactions exhibited excellent chemoselectivity, good to excellent yields and broad functional group tolerance.

The first formation of (1Z)-1-alkylidene-1H-isobenzofuranium amides and 1H-inden-1-ones: Acid-promoted 5-exo cyclization and hydration/aldol condensation reactions of o-ethynylbenzophenones

(1Z)-1-(2,2-Dimethylpropylidene)-1H-isobenzofuranium bis(trifluoromethylsulfonyl)amides were synthesized through 5-exo cyclization reactions between sterically encumbered o-alkynylbenzophenones and bis(trifluoromethylsulfonyl)imide (Tf2NH). It

The First Formation of (1Z)-1-Alkylidene-1H-isobenzofuranium Amides and 1H-Inden-1-ones: Acid-Promoted 5-exo Cyclization and Hydration/Aldol Condensation Reactions of o-Ethynylbenzophenones

(1Z)-1-(2,2-Dimethylpropylidene)-1H-isobenzofuranium bis(trifluoromethylsulfonyl)amides were synthesized through 5-exo cyclization reactions between sterically encumbered o-alkynylbenzophenones and bis(trifluoromethylsulfonyl)imide (Tf2NH). It