1597444-74-0

Basic information

• Product Name: (4-methoxyphenyl)(4-phenylisoquinolin-1-yl)methanone
• Synonyms: (4-methoxyphenyl)(4-phenylisoquinolin-1-yl)methanone
• CAS NO: 1597444-74-0
• Molecular Weight: 339.393
• Mol File: 1597444-74-0.mol

Chemical Properties

• CAS DataBase Reference: (4-methoxyphenyl)(4-phenylisoquinolin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)(4-phenylisoquinolin-1-yl)methanone(1597444-74-0)
• EPA Substance Registry System: (4-methoxyphenyl)(4-phenylisoquinolin-1-yl)methanone(1597444-74-0)

Safety Data

• Hazardous Substances Data: 1597444-74-0(Hazardous Substances Data)

Upstream product

• 19571-30-3 4-phenylisoquinoline 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 

Relevant articles and documents

Transition-Metal-Free Acylation of Quinolines and Isoquinolines with Arylmethanols via Oxidative Cross-Dehydrogenative Coupling Reactions

An efficient acylation of quinolines and isoquinolines is described by use of arylmethanols as the acylating agents through a C-C bond formation via an oxidative cross-dehydrogenative coupling (CDC) strategy. This C-aroylation reaction was carried out by use of K2S2O8 as oxidant and methyltrioctylammonium chloride (Aliquat 336) as a transfer agent in MeCN at 80 °C under transition-metal-free conditions.

A transition metal-free Minisci reaction: Acylation of isoquinolines, quinolines, and quinoxaline

Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has been developed employing a cross dehydrogenative coupling (CDC) reaction with aldehydes using substoichiometric amount of TBAB (tetrabutylammonium bromide, 30 mol %) and K2S2O 8 as an oxidant. This intermolecular acylation of electron-deficient heteroarenes provides an easy access and a novel acylation method of heterocyclic compounds. The application of this CDC strategy for acylation strategy has been illustrated in synthesizing isoquinoline-derived natural products.