159770-29-3

Upstream product

• 22586-32-9 N-Benzyloxycarbonylglycine imidazolide 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 67706-69-8 ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate 
• 79-24-3 Nitroethane 
• 180295-80-1 (E)-4-Benzyloxycarbonylamino-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester 

Downstream Products

• 159770-30-6 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid 
• 66056-61-9 3-acetyltetramic acid 
• 159770-35-1 C₁₇H₁₈N₂O₇ 
• 66056-60-8 3-Acetyltetramic acid 

Relevant academic research and scientific papers

1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones

1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.

A cycloaddition Approach to 3-Acyltetramic and 3-Acyltetronic Acids

1,3-Dipolar cycloaddition of nitrile oxides to enamines formed from protected γ-amino- or γ-hydroxy-β-keto esters affords isoxazolecarboxylic esters that can be converted into 3-acyltetramic acids via dihydropyrroloisoxazol-4-ones, or into 3-acyltetronic