22586-32-9Relevant academic research and scientific papers
DNA sequence-specific ligands: XI. The synthesis and binding to DNA of bis-netropsins with the C-ends of their netropsin fragments tethered by tetra- or pentamethylene linkers
Grokhovsky,Nikolaev,Gottikh,Zhuze
, p. 455 - 469 (2002)
Bis-Netropsins with the C-ends of their netropsin fragments tethered via tetra- or pentamethylene linkers and with Gly or L-Lys-Gly residues on their N-ends were synthesized. The footprinting technique was used to study the specificity of bis-netropsin bi
Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides
Gro?elj, Uro?,Golobi?, Amalija,Knez, Damijan,Hrast, Martina,Gobec, Stanislav,Ri?ko, Sebastijan,Svete, Jurij
, p. 667 - 676 (2016)
The synthesis of two novel (+)-isocampholenic acid-derived amines has been realized starting from commercially available (1S)-(+)-10-camphorsulfonic acid. The novel amines as well as (+)-isocampholenic acid have been used as building blocks in the constru
Synthesis of novel 3D-rich α-amino acid-derived 3-pyrazolidinones
Glava?, Jaka,Dahmann, Georg,Po?gan, Franc,Ri?ko, Sebastijan,?tefane, Bogdan,Svete, Jurij,Gro?elj, Uro?
, p. 715 - 726 (2018/01/17)
Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O
An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
Mocci, Rita,De Luca, Lidia,Delogu, Francesco,Porcheddu, Andrea
supporting information, p. 3135 - 3144 (2016/10/09)
An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).
Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters
Fan, Weizheng,Li, Wanfang,Ma, Xin,Tao, Xiaoming,Li, Xiaoming,Yao, Ying,Xie, Xiaomin,Zhang, Zhaoguo
experimental part, p. 9444 - 9451 (2012/01/13)
A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.
One Pot Synthesis of Methyl Aminoacetylcyanoacetates
Hamilakis, Stylianos,Tsolomitis, Athanase
, p. 4313 - 4319 (2007/10/03)
The C-acylation reactions of the methyl cyanoacetate with N-protected glycines by simultaneous activation of the amino acid carbonyl group and the methyl cyanoacetate methylene group using carbonyl diimidazole (CDI) have been here performed. The correspon
1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Dunn, Stephen H.
, p. 765 - 776 (2007/10/03)
1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.
Synthesis and hypolipidemic activity of N-pyridinyl borodipeptidylamides
Duflos, M.,Robert-Piessard, S.,Robert, J. M.,Andriamanamihaja, M.,Baut, G. Le,et al.
, p. 883 - 888 (2007/10/02)
A series of borodipeptide derivatives 7-9, which contain a 6-amino-2,4-dimethylpyridine moiety, was prepared in 3 steps.They were evaluated as hypolipidemic agents in rodents at 20 mg/kg per day.The methioninamide and phenylalaninamide derivatives were th
