159779-85-8

Upstream product

• 159780-20-8 2-(3-Benzyl-2,4,8-trioxo-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 106746-09-2 3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride 
• 159780-12-8 2-phthalimido-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 159780-24-2 4-(ethoxycarbonyl)-1-(4-methoxybenzyl)-3-(methoxycarbonyl)-2-pyridone 
• 1026415-73-5 (4-Benzylcarbamoyl-1-{[2-(tert-butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-1,2-dihydro-pyridin-3-yl)-carbamic acid benzyl ester 
• 159780-17-3 2-(3-Benzyloxycarbonylamino-4-ethoxycarbonyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-18-4 2-(3-benzyloxycarbonylamino-4-carboxy-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-19-5 2-(3-Benzyl-2,4,8-trioxo-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-15-1 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-16-2 2-(3-Carboxy-4-ethoxycarbonyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-13-9 2-phthalimido-N-<2-<(tert-butyldimethylsiloxy)oxy>-3,3,3-trifluoro-1-isopropyl>acetamide 
• 159780-14-0 2-amino-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropyl>acetamide 
• 159780-23-1 4-(ethoxycarbonyl)-3-(methoxycarbonyl)-2-pyridone 
• 147283-20-3 N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-chloroacetamide 

Downstream Products

• 159780-55-9 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 159780-20-8 2-(3-Benzyl-2,4,8-trioxo-1,2,3,4,7,8-hexahydropyrido[3,4-d]-pyrimidin-7-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 142-08-5 2-Pyridone 
• 159780-15-1 2-(4-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-1,2-dihydro-1-pyridyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 

Relevant academic research and scientific papers

Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones

Using molecular modeling and the information derived from X-ray crystal structures of human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonpeptidic inhibitors of HNE, the