159782-19-1 Usage
Quinoline derivative
The compound is based on a quinoline ring, which is a core structure in many biologically active compounds.
Carboxylic acid functional group
A carboxyl group (-COOH) is attached to the 4th carbon of the quinoline ring, which contributes to the compound's acidity and potential reactivity.
Methoxyphenyl group
A methoxy group (-OCH3) is attached to the 2nd carbon of the quinoline ring, which may influence the compound's solubility and lipophilicity.
Biological activity
The compound may have potential therapeutic applications due to its ability to interact with biological targets, such as enzymes or receptors.
Pharmaceutical applications
The compound can be used as a building block in the synthesis of various biologically active compounds and pharmaceutical intermediates.
Organic synthesis
The compound can be used in organic synthesis to create new compounds with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 159782-19-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,7,8 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 159782-19:
(8*1)+(7*5)+(6*9)+(5*7)+(4*8)+(3*2)+(2*1)+(1*9)=181
181 % 10 = 1
So 159782-19-1 is a valid CAS Registry Number.
159782-19-1Relevant articles and documents
Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety
Li, Sai,Huang, Qiang,Liu, Yajing,Zhang, Xiaolong,Liu, Shuang,He, Chao,Gong, Ping
, p. 62 - 73 (2013/07/27)
A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.
