159788-70-2Relevant academic research and scientific papers
The o-Amino-Trifluoromethyl Functionality as a Novel Synthon for 4-Fluoroquinolines
Strekowski, Lucjan,Kiselyov, Alexander S.,Hojjat, Maryam
, p. 5886 - 5890 (1994)
2-Substituted 4-fluoroquinolines 3 are obtained by the reaction of 2-(trifluoromethyl)aniline (1) with lithium enolates 2 derived from methyl ketones.A similar reaction of 1 with lithium enolate of acetaldehyde produces 4-fluoroquinoline. 1-Fluoro-3-phenyl-4,6-phenanthroline (18) is obtained by treatment of lithium enolate of acetophenone with 4-(trifluoromethyl)quinolin-3-amine (17).By contrast, (Z)-N-carboxamides 10 and 12 are the products of the reaction of 1 with the respective enolate ions derived from 3-pentanone and isobutyl phenyl ketone.A unified mechanism for the formation of quinolines and carboxamides is proposed.
New triple-helix DNA stabilizing agents
Strekowski, Lucjan,Hojjat, Maryam,Wolinska, Ewa,Parker, Alesia N.,Paliakov, Ekaterina,Gorecki, Tadeusz,Tanious, Farial A.,Wilson, W.David
, p. 1097 - 1100 (2007/10/03)
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA·2polydT and duplex polydA·polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T·A·T triplets and triple/duplex selectivity were designed through a rational approach.
