159820-24-3

Basic information

• Product Name: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine
• Synonyms: {[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amine;159820-24-3;1-[3,5-bis(trifluoromethyl)phenyl]-N-methylmethanamine;1-(3,5-Bis(trifluoromethyl)phenyl)-N-methylmethanamine;SCHEMBL681508;(3,5-bis(trifluoromethyl)phenyl)-N-methylmethanamine;AKOS020235258;CS-0180970;(3,5-bis-trifluoromethyl-benzyl)-methylamine;(3,5-bis-trifluoromethyl-benzyl)-methyl-amine;EN300-206498;N-(3,5-bistrifluoromethylbenzyl)-N-methylamine;{[3,5-bis(trifluoromethyl)phenyl]methyl}methylamine
• CAS NO: 159820-24-3
• Molecular Formula: C10H9F6N
• Molecular Weight: 257.179
• Mol File: 159820-24-3.mol

Chemical Properties

• CAS DataBase Reference: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(159820-24-3)
• EPA Substance Registry System: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine(159820-24-3)

Safety Data

• Hazardous Substances Data: 159820-24-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique structural features and reactivity. The strong electron-withdrawing nature and amine functionality enable the creation of a wide range of drug candidates with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, [3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine serves as a key building block for the creation of complex organic molecules. Its electron-withdrawing properties and amine group facilitate various chemical transformations, making it a useful reagent for the development of new compounds with specific properties and applications.
Used in Material Science:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is also utilized in material science for the development of novel materials with unique properties. [3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine's structural characteristics and reactivity can be harnessed to create materials with enhanced performance in areas such as electronics, coatings, and adhesives.
Used in Research and Development:
[3,5-Bis(trifluoromethyl)phenyl]methyl(methyl)amine is frequently employed in research and development settings to explore new reaction pathways, study the effects of electron-withdrawing groups on molecular properties, and develop new synthetic methods. Its versatility and reactivity make it an essential tool for advancing the field of organic chemistry and related disciplines.

Upstream product

• 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde 
• 74-89-5 methylamine 
• 75462-59-8 3,5-bis(trifluoromethyl)benzyl chloride 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 74-88-4 methyl iodide 

Downstream Products

• 168541-85-3 N-[3,5-Bis(trifluoromethyl)benzyl]-8-(4-fluorophenyl)-5,6-dihydro-N, 6-dimethyl-5-oxo-7-pyrido[4,3-b]pyridine carboxamide 
• 168541-21-7 N-[3,5-Bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-1,2-dihydro-N, 2-dimethyl-1-oxo-3-pyrido[3,4-c]pyridine carboxamide 
• 168541-26-2 N-[3,5-Bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-1,2-dihydro-N, 2-dimethyl-1-oxo-3-pyrido[4,3-c]pyridine carboxamide 
• 849619-17-6 N-(3,5-bis-trifluoromethyl-benzyl)-2-chloro-N-methyl-nicotinamide 
• 849619-22-3 N-(3,5-bis-trifluoromethyl-benzyl)-2-chloro-4-iodo-N-methyl-nicotinamide 
• 629956-38-3 N-(3,5-bistrifluoromethylbenzyl)-N-methyl-aminocarbonyl chloride 
• 907182-61-0 6'-chloro-2-methyl-[3,4']bipyridinyl-3'-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 
• 334477-11-1 2-(4-Fluoro-2-methyl-phenyl)-3-oxo-piperazine-1-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide 

Relevant articles and documents

Bifunctional Br?nsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα-Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones

The catalytic asymmetric synthesis of both α-substituted and α,α-disubstituted (quaternary) β-tetralones through direct α-functionalization of the corresponding β-tetralone precursor remains elusive. A designed Br?nsted base-squaramide bifunctional catalyst promotes the conjugate addition of either unsubstituted or α-monosubstituted β-tetralones to nitroalkenes. Under these reaction conditions, not only enolization, and thus functionalization, occurs at the α-carbon atom of the β-tetralone exclusively, but adducts including all-carbon quaternary centers are also formed in highly diastereo- and enantioselective manner.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - Neurokinin-1 antagonist peptidomimetics

A reported mixed opioid agonist - neurokinin 1 receptor (NK1R) antagonist 4 (Dmt-D-Arg-Aba-Gly-(3′,5′-(CF3)2)NMe-benzyl) was modified to identify important features in both pharmacophores. The new dual ligands were tested in vitro and subsequently two compounds (lead structure 4 and one of the new analogues 22, Dmt-D-Arg-Aba-β-Ala-NMe-Bn) were selected for in vivo behavioural assays, which were conducted in acute (tail-flick) and neuropathic pain models (cold plate and von Frey) in rats. Compared to the parent opioid compound 33 (without NK1R pharmacophore), hybrid 22 was more active in the neuropathic pain models. Attenuation of neuropathic pain emerged from NK1R antagonism as demonstrated by the pure NK1R antagonist 6. Surprisingly, despite a lower in vitro activity at NK1R in comparison with 4, compound 22 was more active in the neuropathic pain models. Although potent analgesic effects were observed for 4 and 22, upon chronic administration, both manifested a tolerance profile similar to that of morphine and cross tolerance with morphine in a neuropathic pain model in rat.

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS

The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(=O)OR7 or C1-4 alkyl optionally substituted with hyd

PROCESS FOR THE PREPARATION OF 3,5-BIS (TRIFLUOROMETHYL)-N-METHYLBENZYLAMINE

The invention concerns a process for the preparation of 3,5-bis(trifluoromethyl)-N- methyl-benzylamine by means of an amino-dehalogenation reaction, more in particular starting from a 3,5-bis(trifluoromethyl)-benzyl halide, in particular starting from 3,5-bis(trifluoromethyl)-benzyl chloride and a new process for preparation of the latter.

TACHYKININ RECEPTOR ANTAGONISTS

The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.