1598378-97-2Relevant academic research and scientific papers
Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B
McGowan, David C.,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Smyej, Ilham,Last, Stefaan,Pieters, Serge,Embrechts, Werner,Khamlichi, Mourad Daoubi,Thoné, Tine,Van Schoubroeck, Bertrand,Mostmans, Wendy,Wuyts, Debbie,Verstappen, Dorien,Scholliers, Annick,De Pooter, Dorien,Dhuyvetter, Deborah,Borghys, Herman,Tuefferd, Marianne,Arnoult, Eric,Hong, Jin,Fanning, Gregory,Bollekens, Jacques,Urmaliya, Vijay,Teisman, Ard,Horton, Helen,Jonckers, Tim H. M.,Raboisson, Pierre
, p. 6137 - 6151 (2017/08/02)
Pyrrolo[3,2-d]pyrimidines were identified as a new series of potent and selective TLR7 agonists. Compounds were optimized for their activity and selectivity over TLR8. This presents an advantage over recently described scaffolds that have residual TLR8 ac
PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
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, (2014/05/07)
This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and /or therapy of diseases.
