159839-23-3

Usage

Uses

Used in Pharmaceutical Industry:
4-METHOXYPHENOL-2,3,5,6-D4 is used as a labeled analog for [application reason] in the pharmaceutical industry. Its stable isotope labeling allows for the tracking and analysis of its behavior in biological systems, which can be beneficial for studying drug metabolism, pharmacokinetics, and pharmacodynamics.
Used in Chemical Research:
In the field of chemical research, 4-METHOXYPHENOL-2,3,5,6-D4 is used as a stable isotope-labeled compound for [application reason]. Its deuterium labeling can help in understanding the effects of isotopic substitution on chemical reactions and reaction mechanisms, providing valuable insights into the fundamental aspects of chemistry.
Used in Environmental Studies:
4-METHOXYPHENOL-2,3,5,6-D4 is used as a tracer compound for [application reason] in environmental studies. The stable isotope labeling can be utilized to track the transport, fate, and behavior of the compound in the environment, which can be crucial for assessing its potential impact on ecosystems and human health.
Used in Analytical Chemistry:
In analytical chemistry, 4-METHOXYPHENOL-2,3,5,6-D4 is used as an internal standard for [application reason]. Its stable isotope labeling makes it an ideal candidate for quantification and identification of similar compounds in complex mixtures, improving the accuracy and precision of analytical methods.

Upstream product

• 31405-33-1 2,3,5,6-tetrabromo-4-methoxyphenol 
• 54887-54-6 anisole-d₈ 
• 100-66-3 methoxybenzene 
• 811-98-3 d⁽⁴⁾-methanol 
• 71589-26-9 perdeuteriohydroquinone 
• 150-76-5 4-methoxy-phenol 
• 2641-89-6 2,3,5,6-tetrabromohydroquinone 

Downstream Products

• 21383-12-0 2,3,4,5-tetradeuterio-1,4-dimethoxybenzene 

Relevant academic research and scientific papers

Aqueous Oxidations Started by TiO2 Photoinduced Holes Can Be a Rate-Determining Step

In aqueous TiO2 photocatalytic hydroxylation of weakly polar aromatics, a series of inverse H/D KIEs of 0.7–0.8 were observed, which is different than the normal H/D kinetic isotope effects (KIEs) usually observed for polar aromatics. This result indicated that the oxidation started by photo-induced hvb + can be the rate-determining step.

Hydrogen Isotope Exchange with Iridium(I) Complexes Supported by Phosphine-Imidazolin-2-imine P,N Ligands

Phenylene-bridged hybrid phosphine-imidazolin-2-imineRP,NR′ligands (R=Ph, Cy, i-Pr, t-Bu; R′=Me, i-Pr) were prepared from 1,2-dibromobenzene by palladium-catalyzed C–N coupling with 1,3,4,5-tetramethylimidazolin-2-imine or 1,3-diisopropyl-4,5-dimethylimidazolin-2-imine, followed by lithiation with tert-butyllithium and reaction with the chlorophosphines (R2PCl). Their reaction with the dimeric iridium complex [Ir(cod)Cl]2(cod=1,5-cyclooctadiene) and subsequent anion exchange with sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (NaBArF24) or potassium hexafluorophosphate (KPF6) afforded iridium complexes of the type [(RP,NR′)Ir(cod)]BArF24or [(RP,NR′)Ir(cod)]PF6, respectively. The latter PF6salts were structurally characterized, revealing short Ir—N bonds as an indication of electron-rich nitrogen donor atoms. The former complexes were tested for their applicability in catalytic H/D exchange. In particular, the complex with the ligandt-BuP,NMeshowed remarkable performance in H/D exchange with a broad range of aromatic substrates, including ketones, amides, esters, heterocycles and nitro compounds, and also promoted H/D exchange at aromatic Boc-protected amines, benzylamines and methoxy derivatives. (Figure presented.).

Platinum on carbon-catalyzed H-D exchange reaction of aromatic nuclei due to isopropyl alcohol-mediated self- activation of platinum metal in deuterium oxide

An efficient and simple deuteration method of arenes using the platinum on carbon-isopropyl alcohol-cyclohexane-deuterium oxide combination under hydrogen gas-free conditions was accomplished. Since the hydrogen-deuterium exchange reaction cannot be promoted without isopropyl alcohol, zerovalent platinum metal (on carbon) is self-activated by the in situ-generated very low amount of hydrogen or hydrogen-deuterium gas derived from isopropyl alcohol or isopropyl alcohol-d1. Deuterium-labeled compounds with high deuterium contents can be easily isolated by the filtration of platinum on carbon and simple extraction. The present hydrogen gas-free method is safe from the viewpoint of process chemistry and various arenes possessing a variety of reducible functionalities within the molecule could be effectively and directly deuterium-labeled without undesired reduction. Copyright

Synthesis of highly deuterium-labeled (R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Two highly deuterium-labeled compounds, (R)-K-13675-d11 and (R)-K-13675-d7, were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacok