159909-89-4Relevant academic research and scientific papers
A family of chiral metal-organic frameworks
Gedrich, Kristina,Heitbaum, Maja,Notzon, Andreas,Senkovska, Irena,Froehlich, Roland,Getzschmann, Juergen,Mueller, Uwe,Glorius, Frank,Kaskel, Stefan
, p. 2099 - 2106 (2011)
Chiral metal-organic frameworks with a three-dimensional network structure and wide-open pores (>30) were obtained by using chiral trifunctional linkers and multinuclear zinc clusters. The linkers, H3ChirBTB-n, consist of a 4,4′,4′′-benzene-1,3
Mechanistic investigations of the Mukaiyama aldol reaction as a two part enantioselective reaction
Patel, Sachin G.,Wiskur, Sheryl L.
scheme or table, p. 1164 - 1166 (2009/06/28)
Herein, we report a mechanistic investigation of an enantioselective tandem Mukaiyama aldol reaction, consisting of a carbon-carbon bond-forming reaction and a silylation protection step in which the enantioselectivity results exclusively from the silylation step. The reaction is carried out in the presence of a Lewis base paired with a chiral quarternary ammonium salt. Mechanistic studies indicate that the enantioselectivity of the silylation step is a kinetic resolution of the aldolate intermediate. The effects of sterics and electronics on the aldehyde starting material are also presented.
