1599432-08-2 Usage
Description
NIBR189, also known as (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one, is a selective Epstein-Barr virus-induced gene 2 (EBI-2) receptor antagonist. It plays a crucial role in modulating immune responses, particularly those related to auto-immune diseases. NIBR189 has the potential to be a promising pharmaceutical candidate for various applications in the medical field.
Uses
Used in Pharmaceutical Industry:
NIBR189 is used as a selective EBI-2 receptor antagonist for modulating immune responses related to auto-immune diseases. By targeting the EBI-2 receptor, NIBR189 can potentially help in the treatment and management of various auto-immune conditions.
Used in Auto-immune Disease Treatment:
NIBR189 is used as a therapeutic agent for the treatment of auto-immune diseases. Its selective antagonism of the EBI-2 receptor can help in regulating the immune system and reducing the severity of auto-immune reactions, leading to improved patient outcomes.
Used in Immunological Research:
NIBR189 is used as a research tool for studying the role of EBI-2 receptors in immune responses and auto-immune diseases. Its selective antagonism can provide valuable insights into the underlying mechanisms of these conditions and contribute to the development of novel therapeutic strategies.
Biological Activity
nibr189 is a small molecule antagonist of the epstein-barr virus-induced gene 2 (ebi2; gpr183) receptor with ic50 of 16 nm(binding) and 11 nm (functional).
Check Digit Verification of cas no
The CAS Registry Mumber 1599432-08-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,9,9,4,3 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1599432-08:
(9*1)+(8*5)+(7*9)+(6*9)+(5*4)+(4*3)+(3*2)+(2*0)+(1*8)=212
212 % 10 = 2
So 1599432-08-2 is a valid CAS Registry Number.
1599432-08-2Relevant articles and documents
Identification and characterization of small molecule modulators of the epstein-barr virus-induced gene 2 (EBI2) receptor
Gessier, Francois,Preuss, Inga,Yin, Hong,Rosenkilde, Mette M.,Laurent, Stephane,Endres, Ralf,Chen, Yu A.,Marsilje, Thomas H.,Seuwen, Klaus,Nguyen, Deborah G.,Sailer, Andreas W.
, p. 3358 - 3368 (2014/05/20)
Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) (Nature 2011, 475, 524; 519). EBI2 is highly expressed in immune cells (J. Biol. Chem. 2006, 281, 13199), and its activation has been sho
