1599457-97-2Relevant academic research and scientific papers
Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents
Wang, Xiu-Jun,Yang, Ming-Li,Zhang, Lan-Ping,Yao, Tong,Chen, Cheng,Mao, Lian-Gang,Wang, Yin,Wu, Jie
, p. 589 - 592 (2014/05/06)
A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 μmol/L (mononuclear tumor cell line (U937)) and 5.58 μmol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA.
