1599460-40-8Relevant academic research and scientific papers
Synthesis of Bisflavanol-Type Natural Products and Their Analogues via Self-Coupling of C8-Methylol Catechin Derivatives
Huang, Deng-Ming,Li, Hui-Jing,Wu, Yan-Chao,Zhao, Yan
supporting information, p. 3127 - 3141 (2019/08/07)
A highly efficient and regioselective self-coupling of C8-methylol catechin derivatives is developed for the synthesis of dimeric flavanol analogues under metal-free and mild conditions. Its applicability is showcased by the efficient synthesis of bisflav
Total synthesis of (-)-bis-8,8′-catechinylmethane isolated from cocoa liquor
Pariollaud, Marie,Cockrell, Jennifer,Selenski, Carolyn
, p. 2484 - 2486 (2014/05/06)
An efficient synthesis of bis-8,8′-catechinylmethane, a dimeric flavanol linked through a methylene bridge, is described. Our strategy involved a regioselective coupling via a trifluoroacetic anhydride condensation reaction followed by ketone reduction to the methylene employing new conditions (lithium aluminum hydride and hexafluorophosphoric acid).
