1599529-29-9

Upstream product

• 227609-88-3 4-fluoro-3-iodobenzaldehyde 
• 1599529-24-4 2,2,2-trifluoro-1-(2-fluoro-5-((4-fluorophenyl)(hydroxy)methyl)phenyl)ethanone 
• 1599529-26-6 2,2,2-trifluoro-1-(2-fluoro-5-(4-fluorobenzoyl)phenyl)ethanone 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 1599529-27-7 1-(2-amino-5-(4-fluorobenzoyl)phenyl)-2,2,2-trifluoroethanone 
• 1599529-28-8 N-methyl-2-(methylimino)-4-phenylbutanamide 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1599530-86-5 3-benzyl-6-((4-fluorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-N-methyl-4-(trifluoromethyl)quinolin-2-carboxamide 

Relevant academic research and scientific papers

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.