3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

Base Information

Chemical Name:3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide
CAS No.:1599529-29-9
Molecular Formula:C₂₆H₁₈F₄N₂O₂
Molecular Weight:466.435
Hs Code.:

Synonyms:3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

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Chemical Property of 3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

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Technology Process of 3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

There total 6 articles about 3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599529-27-7
1-(2-amino-5-(4-fluorobenzoyl)phenyl)-2,2,2-trifluoroethanone

: 1599529-28-8
N-methyl-2-(methylimino)-4-phenylbutanamide

: 1599529-29-9
3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

Guidance literature:: 1-(2-amino-5-(4-fluorobenzoyl)phenyl)-2,2,2-trifluoroethanone; N-methyl-2-(methylimino)-4-phenylbutanamide; In dimethyl sulfoxide; at 100 ℃; for 0.0166667h;

With benzenesulfonic acid; In dimethyl sulfoxide; at 130 ℃; for 3h;

Reference yield:

: 227609-88-3
4-fluoro-3-iodobenzaldehyde

: 1599529-29-9
3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.11 h / 20 °C / Cooling with acetone-dry ice; Inert atmosphere

1.2: 0.54 h / Cooling with acetone-dry ice; Inert atmosphere

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; potassium bromide; sodium hydrogencarbonate / dichloromethane; water / 0.42 h / Cooling with ice

3.1: ammonia / dimethyl sulfoxide / 2.01 h / 100 °C / Sealed tube

4.1: dimethyl sulfoxide / 0.02 h / 100 °C

4.2: 3 h / 130 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1599529-24-4
2,2,2-trifluoro-1-(2-fluoro-5-((4-fluorophenyl)(hydroxy)methyl)phenyl)ethanone

: 1599529-29-9
3-benzyl-6-(4-fluorobenzoyl)-N-methyl-4-(trifluoromethyl)quinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; potassium bromide; sodium hydrogencarbonate / dichloromethane; water / 0.42 h / Cooling with ice

2.1: ammonia / dimethyl sulfoxide / 2.01 h / 100 °C / Sealed tube

3.1: dimethyl sulfoxide / 0.02 h / 100 °C

3.2: 3 h / 130 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; sodium hydrogencarbonate; potassium bromide; In dichloromethane; water; dimethyl sulfoxide;