1599531-56-2Relevant academic research and scientific papers
6-Substituted quinolines as RORγt inverse agonists
Barbay, J. Kent,Cummings, Maxwell D.,Abad, Marta,Castro, Glenda,Kreutter, Kevin D.,Kummer, David A.,Maharoof, Umar,Milligan, Cynthia,Nishimura, Rachel,Pierce, Joan,Schalk-Hihi, Celine,Spurlino, John,Tanis, Virginia M.,Urbanski, Maud,Venkatesan, Hariharan,Wang, Aihua,Woods, Craig,Wolin, Ronald,Xue, Xiaohua,Edwards, James P.,Fourie, Anne M.,Leonard, Kristi
, p. 5277 - 5283 (2017/10/30)
We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-position that
METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt
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Paragraph 0881, (2014/05/07)
The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
