159968-52-2

Usage

Uses

Used in Perfume and Flavoring Industry:
3,5-diallyl-2-hydroxy-benzaldehyde is used as a key ingredient for creating distinct scents and flavors in perfumes and flavorings due to its unique odor and yellow color.
Used in Pharmaceutical Industry:
3,5-diallyl-2-hydroxy-benzaldehyde is used as a potential therapeutic agent for its antimicrobial, antioxidant, and anti-inflammatory properties. It is also being studied for its potential as an anti-cancer agent.
Used in Food Preservation:
3,5-diallyl-2-hydroxy-benzaldehyde is used as a natural food preservative to inhibit the growth of harmful bacteria and fungi, thereby extending the shelf life of food products.

Upstream product

• 84682-15-5 3-allyl-2-(allyloxy)benzaldehyde 
• 24019-66-7 3-allylsalicylaldehyde 
• 106-95-6 allyl bromide 

Downstream Products

• 1075725-60-8 2-(4-benzylpiperazin-1-yl)-N'-(3,5-diallyl-2-hydroxybenzylidene)acetohydrazide 

Relevant academic research and scientific papers

Procaspase-3 activation as an anti-cancer strategy: Structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3

A goal of personalized medicine as applied to oncology is to identify compounds that exploit a defined molecular defect in a cancerous cell. A compound called procaspase-activating compound 1 (PAC-1) was reported that enhances the activity of procaspase-3 in vitro and induces apoptotic death in cancer cells in culture and inmouse xenograft models. Experimental evidence indicates that PAC-1 activates procaspase-3 in vitro through chelation of inhibitory zinc ions. Described herein is the synthesis and biological activity of a family of PAC-1 derivativeswhere key functional groups have been systematically altered. Analysis of these compounds reveals a strong correlation between the in vitro procaspase-3 activating effect and their ability to induce death in cancer cells in culture. Importantly, we also show that a fluorescently labeled version of PAC-1 co-localizes with sites of caspase-3 activity in cancer cells. The data presented herein further bolster the hypothesis that PAC-1 induces apoptosis in cancer cells through the direct activation of procaspase-3, has implications for the design and discovery of next-generation procaspase-3 activating compounds, and sheds light on the anti-apoptotic role of cellular zinc.

COMPOSITIONS AND METHODS INCLUDING CELL DEATH INDUCERS AND PROCASPASE ACTIVATION

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.