15997-19-0

Usage

Type of compound

Chlorinated cyclopropane derivative

Physical state

Colorless liquid

Odor

Pungent

Flammability

Highly flammable

Usage

Intermediate in the synthesis of other organic compounds

Applications

Reagent in organic synthesis, building block for pharmaceuticals, pesticides, and other chemicals

Hazard classification

Hazardous substance

Handling precautions

Handle with care due to flammability and potential health risks

Upstream product

• 67-66-3 chloroform 
• 563-47-3 3-Chloro-2-methylpropene 

Downstream Products

• 1378866-61-5 1-(3,3-dichloro-1,1-dimethylprop-2-ene-1-yl)-2-methylbenzene 
• 1378866-62-6 1-(3,3-dichloro-1,1-dimethylprop-2-ene-1-yl)-4-methylbenzene 
• 149511-11-5 N-(4-nitrobenzylidene)-1-(1-methyl-2,2-dichlorocyclopropyl)methylamine 
• 149511-09-1 (4-{[(E)-2,2-Dichloro-1-methyl-cyclopropylmethylimino]-methyl}-phenyl)-dimethyl-amine 
• 149511-10-4 2-{[(E)-2,2-Dichloro-1-methyl-cyclopropylmethylimino]-methyl}-phenol 
• 149511-08-0 (2,2-Dichloro-1-methyl-cyclopropylmethyl)-[1-phenyl-meth-(E)-ylidene]-amine 

Relevant academic research and scientific papers

Preparation of Various 1,1-Dihalo-2-haloalkylcyclopropanes and 1,1,2-Trihalocyclopropanes and their Reduction to Dihalides using Tributyltin Hydride

The title compounds, most of which were obtained by dihalocarbene addition to the corresponding alkenes, are generally reduced to dihalides in good yields. 1,1-Dichloro-2-chloromethyl-2-methylcyclopropane and all the tribromides investigated are attacked regioselectively at the gem-dihalo moiety, yielding isomeric mixtures of 1-halo-2-haloalkylcyclopropanes.Trihalides containing both bromo and chloro substituents are always attacked at the C-Br bond; as a consequence substituted 2-bromomethyl-1,1-dichlorocyclopropanes undergo ring opening and form 4,4-dichloro-1-butene derivatives.

2,2-Dihalo-1(3)-lower alkyl-cyclopropylalkylthio benzimidazole derivatives, compositions thereof and method of use in treating tapeworms and whipworms

Benzimidazole derivatives are provided having the structure STR1 wherein R1 is lower alkyl or phenyl-lower alkyl, R2 and R3 are the same or different and are hydrogen or lower alkyl, R4 is lower alkyl or phenyl, and R5 and R6 are the same or different and are chlorine, bromine, fluorine or iodine, m is 0 to 3, n is 0 to 3, and m + n is ≤ 5, and physiologically acceptable salts thereof. These compounds are especially useful in treating or preventing tapeworm and whipworm infestation in mammalian species or poultry.

Sulfoxide derivatives of benzimidazoles

Sulfoxide derivatives of benzimidazoles are provided having the structure STR1 wherein R1 is lower alkyl or phenyl-lower alkyl, R2 and R3 may be the same or different and are hydrogen or lower alkyl, R4 is alkylcycloalkyl, halocycloalkyl or cycloalkenyl, and m is 0 to 3, n is 0 to 3, m + n being 5. These compounds are useful as anthelmintic agents.