15997-45-2Relevant articles and documents
Pd(II)-Catalyzed Synthesis of Alicyclic[b]-Fused Pyridines via C(sp2)–H Activation of α,β-Unsaturated N-Acetyl Hydrazones with Vinyl Azides
Nie, Biao,Wu, Wanqing,Jin, Chuanfei,Ren, Qingyun,Zhang, Ji,Zhang, Yingjun,Jiang, Huanfeng
, p. 159 - 171 (2022/01/03)
A new synthetic protocol for alicyclic[b]-fused pyridines with complete regioselectivity from α,β-unsaturated N-acetyl hydrazones and vinyl azides via Pd(II)-catalyzed C–H activation/cyclization/aromatization strategy has been described. A series of five-
An aminocatalyzed michael addition/Iron-Mediated decarboxylative cyclization sequence for the preparation of 2,3,4,6-Tetrasubstituted pyridines: Scope and mechanistic insights
Stivanin, Mateus L.,Duarte, Marcelo,Sartori, Camila,Capreti, Naylil M.R.,Angolini, Celio F.F.,Jurberg, Igor D.
, p. 10319 - 10330 (2018/04/20)
A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.
Copper-mediated synthesis of N-alkenyl-α,β-unsaturated nitrones and their conversion to tri- and tetrasubstituted pyridines
Kontokosta, Dimitra,Mueller, Daniel S.,Mo, Dong-Liang,Pace, Wiktoria H.,Simpson, Rachel A.,Anderson, Laura L.
, p. 2097 - 2104 (2016/04/01)
A Chan-Lam reaction has been used to prepare N-alkenyl-α,β-unsaturated nitrones, which undergo a subsequent thermal rearrangement to the corresponding tri- and tetrasubstituted pyridines. The optimization and scope of these transformations is discussed. I
