159974-55-7

Basic information

• Product Name: TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER
• Synonyms: 2-(2-Oxooxazolidin-3-yl)ethyl 4-Methylbenzenesulfonate;2-(2-Oxo-1,3-oxazolidin-3-yl)ethyl 4-methylbenzenesulphonate, 2-(2-Oxo-1,3-oxazolidin-3-yl)ethyl tosylate;2-(2-Oxo-1,3-oxazolidin-3-yl)ethyl toluene-4-sulphonate
• CAS NO: 159974-55-7
• Molecular Formula: C₁₂H₁₅NO₅S
• Molecular Weight: 285.32
• Mol File: 159974-55-7.mol

Chemical Properties

• Melting Point: 68-69°
• Boiling Point: 528.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• PKA: -1.61±0.20(Predicted)
• CAS DataBase Reference: TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER(159974-55-7)
• EPA Substance Registry System: TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER(159974-55-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 159974-55-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER is used as a reagent for its capacity to participate in various chemical reactions, such as esterification, amidation, and alkylation. Its ethyl ester group makes it a valuable intermediate for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER is used as a building block for the synthesis of pharmaceuticals. Its versatility in chemical reactions and its role as an intermediate contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER is utilized as a building block for the synthesis of agrochemicals. Its chemical properties allow for the creation of new compounds that can be used in agricultural applications, such as pesticides and herbicides, to improve crop protection and yield.

Upstream product

• 3356-88-5 N-(2'-hydroxyethyl)-2-oxazolidone 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 159974-46-6 3-(2-Cyclohexylamino-ethyl)-oxazolidin-2-one 
• 159974-38-6 3-[2-(4-Methoxy-phenylamino)-ethyl]-oxazolidin-2-one 
• 22455-79-4 3-(2-anilino-ethyl)-oxazolidin-2-one 
• 159974-40-0 2-[2-(2-Oxo-oxazolidin-3-yl)-ethylamino]-benzoic acid methyl ester 
• 159974-43-3 N-{4-[2-(2-Oxo-oxazolidin-3-yl)-ethylamino]-phenyl}-acetamide 
• 1273326-48-9 Methyl 4-[(4E)-3-[4-(methoxycarbonyl)benzyl]-5-{2-[2-(2-oxo-1,3-oxazolidin-3-yl)ethoxy]-phenyl}pent-4-en-1-yl]benzoate 
• 637022-47-0 3-[2-(5-methoxy-2-methyl-phenylamino)-ethyl]-oxazolidin-2-one 
• 159974-42-2 3-[2-(2-Chloro-5-trifluoromethyl-phenylamino)-ethyl]-oxazolidin-2-one 
• 159974-44-4 N-{3-[2-(2-Oxo-oxazolidin-3-yl)-ethylamino]-phenyl}-acetamide 

Relevant articles and documents

AROMATIC AMIDES

This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Use of 2-Oxazolidinones As Latent Aziridine Equivalents. III. Preparation of N-Substituted Piperazines.

A number of N-aryl and N-alkyl substituted piperazines 1 were prepared from variously substituted 2-oxazolidinone derivatives 3.The method involved treatment of 3 with HBr in glacial acetic acid followed by heating the resulting ring-opened salts 5 in alcoholic solvent.The piperazines 1a-1q were isolated by crystallization in yields ranging from 23-91percent.