159990-95-1Relevant academic research and scientific papers
Total synthesis of the antifungal depsipeptide petriellin A
Sleebs, Marianne M.,Scanlon, Denis,Karas, John,Maharani, Rani,Hughes, Andrew B.
, p. 6686 - 6693 (2011)
We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected lin
DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES
-
, (2008/06/13)
Novel diamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula STR1 wherein: Z is amino, lower alkylamino, di-(lower alkyl)amino R 9 C(O) NH--or an optionally substituted guanidino group;R 1 is hydrogen or R. sup.7 R 8 N--;R 2 is hydrogen, lower alkyl, cyclolower alkyl, aryllower alkyl or heteroaryllower alkyl; and R 3 is hydrogen, lower alkyl or cyclolower alkyl; or R 2 and R 3, together with the carbon to which they are attached, comprise a 3-7 membered carboxyclic ring;R. sup.4 is hydrogen, lower alkyl, aryl lower alkyl or heteroaryllower alkyl; R 5 and R 6 are independently hydroxy, lower alkoxy, amino, aryllower alkoxy, lower alkylamino and di-(lower alkyl) amino;R 7 is R 9 C(O)--or R 10 SO. sub.2--; and R 8 is hydrogen, lower alkyl, aryllower alkyl or aryl; or R. sup. 7 and R 8, together with the nitrogen to which they are attached, comprise a 5-7 membered ring;R 9 is lower alkyl, aryllower alkyl, aryl, heteroaryllower alkyl, heteroaryl, lower alkoxy, aryllower alkoxy, amino, alkylamino or dialkylamino;R. sup.10 is lower alkyl, aryl lower alkyl, aryl, heteroaryl lower alkyl, amino, lower alkylamino, di-(lower alkyl)amino or heteroaryl;n is 1, 2, 3, 4 or 5; and m is 1, 2, 3, 4 or 5;or a pharmaceutically acceptable addition salt thereof, useful in the treatment of cardiovascular disorders, are disclosed.
