160031-97-0

Upstream product

• 126443-14-9 1-(4-chlorophenyl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 109-77-3 malononitrile 
• 28081-12-1 3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one 
• 459-57-4 4-fluorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 281225-36-3 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 281225-35-2 7-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-3-(2-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 

Relevant academic research and scientific papers

Application of salicylic acid as an eco-friendly and efficient catalyst for the synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives

In this study, three eco-friendly, efficient, and convenient protocols have been reported for one-pot synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives using salicylic acid as a catalyst under solvent-free condition. The reported protocols offer several significant advantages such as the application of a nontoxic, neutral, and cheap catalyst, environmentally friendly conditions, the easy isolation of products by filtering, short reaction times, simple methodology, and good yields.

One-pot synthesis of 2-amino-3-cyanopyridines and hexahydroquinolines using eggshell-based nano-magnetic solid acid catalyst via anomeric-based oxidation

Abstract: In the present research, the eggshell as a hazardous waste by European Union regulations was converted to a valuable catalyst, namely nano-Fe3O4@(HSO4)2. The as-prepared catalyst, first, was characterized using different techniques, including Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Back-titration method confirmed the loading of a high surface density of acidic group, namely 8.8?mmol HSO4 per gram of the catalyst. The catalytic property of the as-prepared catalyst was examined in the synthesis of 2-amino-3-cyanopyridines via anomeric-based oxidation (ABO), and hexahydroquinolines derivatives. High yield, short reaction time, solvent-free condition, waste to wealth, and optimization with the design of experiment are the major advantages of the present work. Taken together, these results suggest the conversion of waste to wealth products around the world and usage in organic transformation. Graphic abstract: [Figure not available: see fulltext.].

Sulfonic acid supported phosphonium based ionic liquid functionalized SBA-15 for the synthesis of 2-amino-3-cyano-4,6-diarylpyridines

The surface of SBA-15 was functionalized using diphenylphosphine and then it was treated with butane sultone and sulfuric acid to obtain Bronsted acid HO3S-phosphonium based ionic liquid functionalized SBA-15 with 4-methylbenzenesulfonate (p-TS

Aqueous media preparation of 2-amino-4,6-diphenylnicotinonitriles using cellulose sulfuric acid as an efficient catalyst

A convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery.

'One pot' synthesis of 2-amino-3-cyano-4,6-diarylpyridines under ultrasonic irradiation and grindstone technology

A simple facile 'one pot' synthesis of 2-amino-3-cyano-4,6-diarylpyridine derivatives via three component reaction of chalcone, malanonitrile and ammonium acetate under ultrasonic irradiation and grindstone technology. All the synthesized compounds have been characterized on the basis of their elemental analyses and spectral data (IR, 1H NMR, 13C NMR and Mass).

Synthesis of ribonucleosides of 2-thioxopyrido [2,3-d]pyrimidines by phase transfer catalysis and their antimicrobial activity

The ribonucleosides viz; 2-thioxo-3,5,7-trisubstituted-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl) pyrido[2,3-d]pyrimidine-4 (1H)-ones have been synthesized via phase transfer ribosylation of 2-thioxo- 3,5,7-trisubstituted pyrido[2,3-d)pyrimidine-4(1H)-ones with 2,3,5-tri-O-benzoyl-β-D- ribofuranosyl bromide in biphasic solvent such as CH2Cl2-50% aqueous NaOH using tetrabutylammonium bromide as phase transfer catalysis (PTC). The synthesized compounds have been characterized by elemental analyses, spectral data and screened for their antimicrobial activity.