1600528-19-5Relevant academic research and scientific papers
HYDROXAMIC ACID DERIVATIVES AND HDAC8 INHIBITORS
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Paragraph 0043, (2016/10/07)
PROBLEM TO BE SOLVED: To provide compounds that are highly active and can highly selectively inhibit HDAC8 functionality, and HDAC8 inhibitors. SOLUTION: Each hydroxamic acid derivative comprise a compound of the general formula (1) in the figure, where φ
Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors
Suzuki, Takayoshi,Muto, Nobusuke,Bando, Masashige,Itoh, Yukihiro,Masaki, Ayako,Ri, Masaki,Ota, Yosuke,Nakagawa, Hidehiko,Iida, Shinsuke,Shirahige, Katsuhiko,Miyata, Naoki
, p. 657 - 664 (2014/03/21)
We recently discovered N-hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol- 4-yl]benzamide (NCC149) as a potent and selective histone deacetylasea 8 (HDAC8) inhibitor from a 151-member triazole compound library using a click chemistry approach. In this wor
