160056-49-5

Basic information

• Product Name: 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine
• CAS NO: 160056-49-5
• Molecular Formula: C₂₂H₄₀N₆O₄Si₂
• Molecular Weight: 508.7618
• Mol File: 160056-49-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 566°C at 760 mmHg
• Flash Point: 296.1°C
• Density: 1.31g/cm³
• Vapor Pressure: 7.85E-13mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine(160056-49-5)
• EPA Substance Registry System: 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine(160056-49-5)

Safety Data

• Hazardous Substances Data: 160056-49-5(Hazardous Substances Data)

Upstream product

• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 5536-17-4 arabinosyl adenine 
• 88121-25-9 9-[3′,5′-O-(1,1,3,3-tetraisopropyldisiloxyl)-2′-O-trifluormethylsulfonyl-β-D-arabinofuranosyl]adenine 
• 87792-02-7 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine 
• 88121-26-0 2'?azido?2'?deoxy?3',5'?O?(1,1,3,3?tetraisopropyldisiloxane?1,3?diyl)adenosine 

Downstream Products

• 1053266-43-5 N-[(2R,3R,3aS,9aR)-2-(6-Amino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl]-3-ethoxy-benzamide 
• 1053641-23-8 [(2R,3R,3aS,9aR)-2-(6-Amino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl]-carbamic acid isobutyl ester 
• 218923-40-1 2'-deoxy-2'-(3-methoxy-4-acetoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 218923-50-3 2'-deoxy-2'-(3-acetoxybenzamido)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 945403-63-4 2'-N-(N-benzyloxycarbonyl-L-isoleucyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-64-5 2'-N-(N-benzyloxycarbonyl-L-threonyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-65-6 2'-N-(N-benzyloxycarbonyl-L-asparaginyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-66-7 2'-N-(N-benzyloxycarbonyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-67-8 2'-N-(N-benzyloxycarbonyl-L-prolyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-68-9 2'-N-(N-α-acetyl-N-ω-benzyloxycarbonyl-L-lysyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-81-6 2'-N-(N-benzyloxycarbonyl-L-isoleucyl-L-phenylalanyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 945403-62-3 2'-N-(N-benzyloxycarbonyl-L-valyl)-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 
• 171502-21-9 9-((2R,3R,3aS,9aR)-3-Benzylamino-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine 

Relevant articles and documents

Synthesis of 2′-N-formamido nucleosides and biological evaluation

The 2′-N-formamide derivatives of adenosine, cytidine, and 9-β-D-arabinofuranosyladenine were synthesized and tested (as triphosphate) for their substrate capacities for the HCV NS5B polymerase.

Synthesis of Phosphoramidite Building Blocks of 2′-Amino-2′-deoxyribonucleosides: New Compounds for Oligonucleotide Synthesis

The chemical synthesis of 2′-amino-2′-deoxyribonucleosides of uracil, cytosine, adenine, and guanine, and their conversion into suitably protected 3′-phosphoramidite building blocks 35-40 for oligonucleotide synthesis are described. The aglycone and the 2′-amino functions were protected using the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group. The synthesis of the 3′-?-succinyl (3′-?-(3-carboxypropanoyl))-substituted starting nucleoside 41 is described and its behavior examined in solution and on solid phase with regard to an anticipated migration during 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) deprotection. Oligonucleotides were prepared using the new building blocks, and their hybridization properties were studied by UV-melting techniques.