160081-17-4

Basic information

• Product Name: (S)-3-((2R,3R)-5-Benzyloxy-2-ethyl-3-phenylsulfanyl-pentanoyl)-4-isopropyl-oxazolidin-2-one
• Synonyms: (S)-3-((2R,3R)-5-Benzyloxy-2-ethyl-3-phenylsulfanyl-pentanoyl)-4-isopropyl-oxazolidin-2-one
• CAS NO: 160081-17-4
• Molecular Weight: 455.618
• Mol File: 160081-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-((2R,3R)-5-Benzyloxy-2-ethyl-3-phenylsulfanyl-pentanoyl)-4-isopropyl-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-((2R,3R)-5-Benzyloxy-2-ethyl-3-phenylsulfanyl-pentanoyl)-4-isopropyl-oxazolidin-2-one(160081-17-4)
• EPA Substance Registry System: (S)-3-((2R,3R)-5-Benzyloxy-2-ethyl-3-phenylsulfanyl-pentanoyl)-4-isopropyl-oxazolidin-2-one(160081-17-4)

Safety Data

• Hazardous Substances Data: 160081-17-4(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 153499-90-2 (S)-3-((E)-5-Benzyloxy-2-ethyl-pent-2-enoyl)-4-isopropyl-oxazolidin-2-one 
• 212000-37-8 (E)-ethyl 5-(benzyloxy)-2-ethylpent-2-enoate 
• 212000-50-5 (E)-5-Benzyloxy-2-ethyl-pent-2-enoyl chloride 
• 212000-48-1 (E)-5-Benzyloxy-2-ethyl-pent-2-enoic acid 
• 19790-60-4 3-Benzyloxypropanal 

Relevant articles and documents

Efficient stereoselective route to β-lactams and their application to the stereoselective synthesis of a key intermediate for carbapenem antibiotic (+)-PS-5

A combination of a stereoselective addition of benzenethiol to α,β-unsaturated carboxylic acid derivatives and a subsequent substitution reaction of the corresponding sulfonium group with O-alkyl-hydroxamate anion has provided a new practical and stereoselective method for the construction of 3,4-disubstituted cis- and trans-β-lactams. A successful application was demonstrated by the formal asymmetric synthesis of (+)-PS-5.