160084-71-9Relevant academic research and scientific papers
Fluorinated taxane compound, preparation method therefor and application of fluorinated taxane compound
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Paragraph 0155; 0160; 0163-0165, (2019/08/30)
The invention discloses a fluorinated taxane compound, a preparation method therefor and an application of the fluorinated taxane compound. The compound has a structural general formula represented bya formula I. Proven by pharmacological experiments, compared with paclitaxel, a series of fluorinated taxane derivatives synthesized by the method have cytotoxicity superior to that of the paclitaxelto a multidrug-resistant human mammary cancer cell line MCF-7/Adr and an ovarian cancer cell line NCI/Adr and represent cytotoxicity superior to that of the paclitaxel to a colon cancer cell line HCT-116 with overexpressed neoplasm stem cells.
C10 cyclopropyl ester substituted taxane compositions
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Page/Page column 7, (2008/06/13)
Compositions comprising a taxane having a cyclopropyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C7, a 2-furyl substituent at C3′ and an isobutoxycarbamate substituent at C3′.
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: Exceptional activity against drug-resistant cancer cells
Ojima, Iwao,Slater, John C.,Michaud, Evelyne,Kuduk, Scott D.,Bounaud, Pierre-Yves,Vrignaud, Patricia,Bissery, Marie-Christine,Veith, Jean M.,Pera, Paula,Bernacki, Ralph J.
, p. 3889 - 3896 (2007/10/03)
A series of new 3'-(2-methyl-1-propenyl) and 3'-(2-methylpropyl) taxoids with modifications at C-10 was synthesized by means of the β-lactam synthon method using 10-modified 7-(triethylsilyl)-10-deacetylbaccatin III derivatives. The new taxoids thus synth
