160088-57-3Relevant academic research and scientific papers
Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs
Cifuentes, Michael,Schilling, Brett,Ravindra, Rudravajhala,Winter, Jacquelyn,Janik, Mark E.
, p. 2761 - 2764 (2006)
A series of modified colchicine and isocolchicine analogs (C-7 substituent) were synthesized and evaluated in vitro against a PC3 cancer cell line and for inhibition of microtubule polymerization. The colchicine analogs all displayed strong inhibition of
Polyaza Heterocycles. Part 2. Nucleophilic Substitution of Halogens in Halogenoquinoxalinocinnolines
Ahmad, Arshad,Dunbar, Linda J.,Green, Iain G.,Harvey, Ian W.,Shepherd, Thomas,et al.
, p. 2751 - 2758 (2007/10/02)
10-Chloroquinoxalinocinnoline readily undergoes methoxydechlorination when treated with sodium methoxide.The 1-, 2-, 3-, 4- and 9-chloro isomers are unreactive towards this reagent, but the 9,10-dichloro derivative undergoes substitution of both chlorines (the 10-position being much the more reactive).The 9- and 10-bromo analogues are both unreactive towards sodium methoxide, but the 9- and 10-fluoro analogues are both highly reactive, to the extent that it has not been possible even to isolate the 10-fluoro compound.Routes to 9- and 10-piperidinoquinoxalinocinnolines are described.
