16013-92-6Relevant academic research and scientific papers
Antineoplastic anthraquinones. II [1]. Design and synthesis of 1,2-heteroannelated anthraquinones
Chang, Pong,Chen, Chia-Fu
, p. 367 - 371 (1996)
Based on the "2-phenyinaphthalene-type" structural pattern hypothesis, a number of heterocycle-fused anthraquinones were designed by taking morindaparvin-A (2a) as the lead structure. The compounds we synthesized and tested for antineoplastic activity include 1,2-alkylenedioxyanthraquinone, naphtho [2,3-f]-quinoxaline-7,12-dione, anthra[1,2-d]imidazole-6,11-dione and naphtho[2,3-f]quinoxaline-7,12-dione derivatives. Most of the synthesized anthraquinones possessed various degrees of anticancer activity. One of these compounds, 2-chloromethyl-1H-anthra[1,2-d]imidazole-6,11-dione (4b), exhibited cytotoxic activity against all tested human carcinoma cell lines.
