160141-86-6Relevant academic research and scientific papers
A novel oxidative side-chain transformation of α-amino acids and peptides by methyltrioxorhenium/H2O2 system
Lazzaro, Francesco,Crucianelli, Marcello,De Angelis, Francesco,Neri, Veronica,Saladino, Raffaele
, p. 9237 - 9240 (2004)
N-Boc derivatives of Met, Cys, and Trp, the properties of which resemble those of the respective amino acid residues present in proteins, are efficiently oxidized by methyltrioxorhenium and H2O2. A high regioselectivity for the oxida
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
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, (2015/05/05)
Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: Versatile and switchable access to functionalized proteins
Bernardes, Goncalo J. L.,Chalker, Justin M.,Errey, James C.,Davis, Benjamin G.
, p. 5052 - 5053 (2008/10/09)
An efficient and robust oxidative elimination of cysteine to dehydroalanine has been discovered. The reaction is induced by O-mesitylenesulfonylhydroxylamine (MSH) and is compatible with methionine. The key elimination has been executed on protein surfaces and allows ready access to different post-translationally modified proteins through conjugate addition of sulfur nucleophiles to dehydroalanine. Treatment of the resulting thioether with MSH results in regeneration of dehydroalanine, allowing a "functional switch" by subsequent addition of a different thiol. Copyright
Amino acid derived thiane oxide and dioxide systems as disposable templates: Synthesis of α-amino ketones, anti-amino alcohols and an amino cyclopentenone
Gamble, Mark P.,Giblin, Gerard M. P.,Montana, John G.,O'Brien, Peter,Ockendon, Timothy P.,Taylor, Richard J. K.
, p. 7457 - 7460 (2007/10/03)
Sulfones and sulfoxides synthesised from methionine and homocysteine thiolactone have been cyclised to amino ketones using potassium bis(trimethylsilyl)amide. Ramberg-Backlund chemistry on one of the sulfones gave an amino cyclopentenone whereas acyclic α-amino ketones and anti-amino alcohols were obtained by Raney nickel desulfurisation of the sulfoxides.
