1601475-96-0Relevant articles and documents
Flexible and modular syntheses of enantiopure 5-cis-substituted prolinamines from l-pyroglutamic acid
Prause, Felix,Kaldun, Johannes,Arensmeyer, Benjamin,Wennemann, Benedikt,Fr?hlich, Benjamin,Scharnagel, Dagmar,Breuning, Matthias
, p. 575 - 586 (2015)
A wide range (25 examples) of 5-cis-substituted prolinamines is prepared in five to ten steps starting from cheap l-pyroglutamic acid. Three routes, differing mainly in the order of introduction of the substituents at the 5-cis position, the pyrrolidine nitrogen atom, and the exocyclic amino function, are successfully developed.