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CAS

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1601475-96-0

(2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1601475-96-0 Structure

  • Basic information

    1. Product Name: (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine
    2. Synonyms: (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine
    3. CAS NO:1601475-96-0
    4. Molecular Formula:
    5. Molecular Weight: 267.371
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1601475-96-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine(1601475-96-0)
    11. EPA Substance Registry System: (2S,5R)-1-benzyl-2-hydroxymethyl-5-phenylpyrrolidine(1601475-96-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1601475-96-0(Hazardous Substances Data)

1601475-96-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1601475-96-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,0,1,4,7 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1601475-96:
(9*1)+(8*6)+(7*0)+(6*1)+(5*4)+(4*7)+(3*5)+(2*9)+(1*6)=150
150 % 10 = 0
So 1601475-96-0 is a valid CAS Registry Number.

1601475-96-0Relevant articles and documents

Flexible and modular syntheses of enantiopure 5-cis-substituted prolinamines from l-pyroglutamic acid

Prause, Felix,Kaldun, Johannes,Arensmeyer, Benjamin,Wennemann, Benedikt,Fr?hlich, Benjamin,Scharnagel, Dagmar,Breuning, Matthias

, p. 575 - 586 (2015)

A wide range (25 examples) of 5-cis-substituted prolinamines is prepared in five to ten steps starting from cheap l-pyroglutamic acid. Three routes, differing mainly in the order of introduction of the substituents at the 5-cis position, the pyrrolidine nitrogen atom, and the exocyclic amino function, are successfully developed.

Core modification of substituted piperidines as Novel inhibitors of HDM2-p53 protein-protein interaction

Pan, Weidong,Lahue, Brian R.,Ma, Yao,Nair, Latha G.,Shipps Jr., Gerald W.,Wang, Yaolin,Doll, Ronald,Bogen, Stéphane L.

, p. 1983 - 1986 (2014/04/17)

The discovery of 3,3-disubstituted piperidine 1 as novel p53-HDM2 inhibitors prompted us to implement subsequent SAR follow up directed towards piperidine core modifications. Conformational restrictions and further functionalization of the piperidine core were investigated as a strategy to gain additional interactions with HDM2. Substitutions at positions 4, 5 and 6 of the piperidine ring were explored. Although some substitutions were tolerated, no significant improvement in potency was observed compared to 1. Incorporation of an allyl side chain at position 2 provided a drastic improvement in binding potency.

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