1601480-52-7

Basic information

• Product Name: N,N-dimethyl-3-phenyl-3-(p-tolyl)propanamide
• Synonyms: N,N-dimethyl-3-phenyl-3-(p-tolyl)propanamide
• CAS NO: 1601480-52-7
• Molecular Weight: 267.371
• Mol File: 1601480-52-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-3-phenyl-3-(p-tolyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-3-phenyl-3-(p-tolyl)propanamide(1601480-52-7)
• EPA Substance Registry System: N,N-dimethyl-3-phenyl-3-(p-tolyl)propanamide(1601480-52-7)

Safety Data

• Hazardous Substances Data: 1601480-52-7(Hazardous Substances Data)

Upstream product

• 4073-42-1 3-phenyl-3-(p-tolyl)propanoic acid 
• 124-40-3 dimethyl amine 
• 23426-02-0 methyl 3-(4-methylphenyl)-3-phenylpropionate 

Downstream Products

• 5632-44-0 1-[3-(4-methylphenyl)-3-phenylpropyl]-N,N-dimethylamine 

Relevant articles and documents

Construction of 3-arylpropylamines using Heck arylations. the total synthesis of cinacalcet hydrochloride, alverine, and tolpropamine

New synthetic routes toward the commercial drugs cinacalcet hydrochloride, alverine, and tolpropamine were developed using a Heck-Matsuda arylation as the key-step. Several reaction conditions were evaluated for the Heck-Matsuda reaction using allylamine derivatives and arenediazonium salts. For cinacalcet hydrochloride, N-formylamide provided the best result, furnishing the synthetic target in a very high overall yield (75% over five steps). For alverine, the best results were obtained using a double Heck-Matsuda strategy, providing alverine in an excellent overall yield (69%) from N-acetyl diallylamine in three steps. Tolpropamine was synthesized in a 46% yield over five steps using an efficient reductive Heck-Matsuda arylation between p-bromo-methylcinnamate with 3-chloro tolyldiazonium salt, generating the ,diaryl propionate that was converted to tolpropamine.