1601483-67-3

Upstream product

• 105804-84-0 methyl 3-((2-methoxy-2-oxoethyl)amino)-3-methylbutanoate 
• 69950-44-3 anhydrous methyl 3-aminoisovalerate hydrochloride 
• 1584148-63-9 5,5-dimethyl-2-(methylsulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 625-05-8 3-amino-3-methylbutanoic acid 
• 1584148-62-8 benzyl 5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1584148-60-6 benzyl 5,5-dimethyl-2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1584149-17-6 C₁₀H₁₂ClN₃O₃S 
• 20989-17-7 (2S)-2-phenylglycinol 
• 1584148-47-9 6-benzyl 7-methyl 5,5-dimethyl-2-(methylthio)-5H-pyrrolo[3,4-d]pyrimidine-6,7(7H)-dicarboxylate 
• 1584148-45-7 1-benzyl 2-methyl (Z)-4-((dimethylamino)methylene)-5,5-dimethyl-3-oxopyrrolidine-1,2-dicarboxylate 
• 1584148-42-4 1-benzyl 2-methyl 5,5-dimethyl-3-oxopyrrolidine-1,2-dicarboxylate 
• 1584148-41-3 methyl 3-(((benzyloxy)carbonyl)(2-methoxy-2-oxoethyl)amino)-3-methylbutanoate 

Downstream Products

• 1584146-05-3 (S)-2-((cyclopropylmethyl)amino)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide 

Relevant academic research and scientific papers

DIHYDROPYRROLIDINO-PYRIMIDINES AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERKl and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics