1601495-01-5Relevant academic research and scientific papers
Ruthenium-catalyzed oxidative alkyne annulation by C-H activation on ketimines
Li, Jie,Ackermann, Lutz
, p. 3342 - 3348 (2014/05/06)
Carboxylate assistance allowed for ruthenium(II)-catalyzed oxidative alkyne annulations by ketimines under an ambient atmosphere of air. The ruthenium catalyst outperformed representative rhodium and palladium complexes, and provided versatile access to differently decorated 1-methylene-1,2- dihydroisoquinolines in a highly step- and atom-economical manner. Detailed mechanistic studies provided evidence for an initial reversible C-H bond activation event.
