16017-53-1

Basic information

• Product Name: 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE
• Synonyms: BUTTPARK 19\07-45;ART-CHEM-BB B003963;CHEMBRDG-BB 3003963;AKOS BBS-00003684;AKOS B003963;1-[(4-CHLOROPHENYL)SULFONYL]PIPERAZINE;1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE;1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE HYDROCHLORIDE
• CAS NO: 16017-53-1
• Molecular Formula: C₁₀H₁₃ClN₂O₂S
• Molecular Weight: 260.74
• Mol File: 16017-53-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 401.7 °C at 760 mmHg
• Flash Point: 196.7 °C
• Appearance: /
• Density: 1.352g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 7.75±0.10(Predicted)
• CAS DataBase Reference: 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE(16017-53-1)
• EPA Substance Registry System: 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE(16017-53-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16017-53-1(Hazardous Substances Data)

Usage

General Description

1-(4-Chloro-benzenesulfonyl)-piperazine is a chemical compound that consists of a piperazine molecule attached to a 4-chlorobenzenesulfonyl group. It is often used as an intermediate in the synthesis of pharmaceutical compounds and is known for its potential pharmacological properties. The 4-chlorobenzenesulfonyl group is a common functional group in many pharmaceuticals and bioactive molecules, and its combination with the piperazine moiety suggests that this compound may have applications in the development of new drugs. Additionally, the presence of the chloro group in the benzene ring gives this compound certain chemical reactivity that can be leveraged in the synthesis of various biologically active molecules. Overall, 1-(4-chloro-benzenesulfonyl)-piperazine is an important compound in medicinal chemistry and drug development.

InChI:InChI=1/C10H13ClN2O2S/c11-9-1-3-10(4-2-9)16(14,15)13-7-5-12-6-8-13/h1-4,12H,5-8H2/p+1

Upstream product

• 110-85-0 piperazine 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 973-63-7 2,4-dinitrophenyl 4-chlorobenzenesulfonate 

Downstream Products

• 1233940-68-5 7-((4-(4-chlorophenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol 
• 888301-46-0 4-[(4-chlorophenyl)sulfonyl]-N-(2,4-difluorophenyl)-1-piperazinecarboxamide 
• 1291058-01-9 1-benzo[b]thiophen-3-yl-3-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]propan-1-ol 
• 1291057-93-6 1-benzo[b]thiophen-3-yl-3-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]propan-1-one 
• 14172-55-5 1-(phenylsulphonyl)piperazine 

Relevant articles and documents

Discovery of Novel Chromone Derivatives Containing a Sulfonamide Moiety as Anti-ToCV Agents through the Tomato Chlorosis Virus Coat Protein-Oriented Screening Method

A number of novel chromone derivatives containing sulfonamide moieties were designed and synthesized, and the activity of compounds against tomato chlorosis virus (ToCV) was assessed using the ToCVCP-oriented screening method. Comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were established based on the dissociation constant (Kd) values of the target compounds, and compound 35 was designed and synthesized with the aid of CoMFA and CoMSIA models. The study of affinity interaction indicated that compound 35 exhibited excellent affinity with ToCVCP with a Kd value of 0.11 μM, which was better than that of the positive control agents xiangcaoliusuobingmi (0.44 μM) and ningnanmycin (0.79 μM). In addition, the in vivo inhibitory effect of compound 35 on the ToCVCP gene was evaluated by the quantitative real-time polymerase chain reaction. ToCVCP gene expression levels of the compound 35 treatment group were reduced by 67.2%, which was better than that of the positive control agent ningnanmycin (59.5%). Therefore, compound 35 can be used as a potential anti-ToCV drug in the future.

Synthesis and biological evaluation of imidazo[2,1-b]thiazole based sulfonyl piperazines as novel carbonic anhydrase ii inhibitors

A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-

Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents

Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was