16017-64-4

Usage

Uses

Used in Pharmaceutical Industry:
Pimethixene is used as an anxiolytic and anti-tension agent for the treatment of anxiety and tension disorders. Its mechanism of action involves the modulation of dopamine and serotonin levels in the brain, leading to a reduction in anxiety and tension symptoms.
Used in Central Nervous System Disorders:
Pimethixene is used as a therapeutic agent for the management of central nervous system disorders characterized by anxiety and tension. Its phenothiazine class of action allows it to effectively alleviate symptoms associated with these conditions, improving the quality of life for affected individuals.
Used in Oral Medication Form:
Pimethixene is available in oral form, making it a convenient and accessible treatment option for patients. It is typically taken one to three times a day, as prescribed by a healthcare professional, ensuring optimal therapeutic effects and patient compliance.

InChI:InChI=1/C13H20N2O3S/c1-12-2-4-13(5-3-12)19(17,18)15-8-6-14(7-9-15)10-11-16/h2-5,16H,6-11H2,1H3

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 141-43-5 ethanolamine 
• 2232-08-8 N-tosylimidazole 

Relevant academic research and scientific papers

DBN hexafluorophosphate salts as convenient sulfonylating and phosphonylating agents

Air-stable N-sulfonyl and N-phosphonyl DBN hexafluorophosphate salts have been synthesised under mild conditions as sulfonylating and phosphonylating agents. These salts are highly efficient in the sulfonylation and phosphonylation of a range of N- and O-nucleophiles to generate sulfonamides, sulfonate esters, phosphoramidates and phosphonate esters in good yields.

One-step cyclization: Synthesis of N -heteroalkyl-N′-tosylpiperazines

Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (SN) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations.

Imidazole-catalyzed monoacylation of symmetrical diamines

Figure Presented. An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for an