16022-61-0Relevant academic research and scientific papers
Utilization of carbon disulfide as a powerful building block for the synthesis of 2-aminobenzoxazoles
Guntreddi, Tirumaleswararao,Allam, Bharat Kumar,Singh, Krishna Nand
, p. 9875 - 9880 (2013)
This protocol describes a novel, mild and convenient route to afford 2-aminobenzoxazoles in high yields, and represents a significant advance towards an environmentally friendly strategy. Aliphatic amines are made to react with carbon disulfide to provide intermediate dithiocarbamates (DTC), which in the presence of 2-aminophenol, subsequently undergo successive intermolecular nucleophilic attack and desulfurization to produce 2-aminobenzoxazoles within 3 h.
