160238-53-9Relevant academic research and scientific papers
Total synthesis of (+)-tautomycin
Shimizu, Satoshi,Nakamura, Sei-Ichi,Nakada, Masahisa,Shibasaki, Masakatsu
, p. 13363 - 13408 (2007/10/03)
A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C1.-C7. fragment A'74 with the C1-C26 fragment B'76 by a modified Yamaguchi method and an aldol reaction of the C17-C26 fragment C 5 with the C1-C16 fragment D 6 using LDA as key steps. The fragments 5 and 6 have been constructed in a stereocontrolled manner, respectively.
Synthetic studies on tautomycin. Stereoselective construction of the C1-C26 region
Nakamura, Sei-Ichi,Shibasaki, Masakatsu
, p. 4145 - 4148 (2007/10/02)
A convergent, stereocontrolled synthesis of the C1-C26 portion of tautomycin has been achieved through the coupling of the fragments 3 and 4 by an aldol condensation.
