1602827-70-2Relevant articles and documents
Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode
Hafner, Andreas,Mancino, Valentina,Meisenbach, Mark,Schenkel, Berthold,Sedelmeier, Joerg
supporting information, p. 786 - 789 (2017/03/01)
A simple and robust procedure for the synthesis and use of thermally unstable dichloromethyllithium in continuous flow mode is described. By utilizing residence times in the range of milliseconds for the generation and electrophilic quench of dichlorometh
Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives
Kedziora, Kinga,Diaz-Rodriguez, Alba,Lavandera, Ivan,Gotor-Fernandez, Vicente,Gotor, Vicente
supporting information, p. 2448 - 2453 (2014/05/06)
An efficient methodology to oxidize β,β-dihalogenated secondary alcohols employing oxygen was achieved in a biphasic medium using the laccase from Trametes versicolor/TEMPO pair, providing the corresponding ketones in a clean fashion under very mild conditions. Moreover, a chemoenzymatic protocol has been applied successfully to deracemize 2,2-dichloro-1-phenylethanol combining this oxidation with an alcohol dehydrogenase-catalyzed bioreduction. the Partner Organisations 2014.