160285-02-9

Upstream product

• 90-02-8 salicylaldehyde 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 93-89-0 benzoic acid ethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 89-95-2 2-methyl-benzyl alcohol 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase

Two series of novel kojic acid analogues (4a–j) and (5a–d) were designed and synthesized, and their mushroom tyrosinase inhibitory activities was evaluated. The result indicated that all the synthesized derivatives exhibited excellent tyrosinase inhibitor

Studies on Absorption and Emission Characteristics of Inclusion Complexes of Some 4-Arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols

The inclusion complexes of a series of 4-arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols have been prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. Th

Impact of inclusion complex formation on antibacterial, antioxidant and anthelmintic activities of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols

Three different 4-arylidenamino-5-phenyl-4H-l,2,4-triazole-3-thiols have been synthesized and their inclusion complexes are prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. The determination of thermodynamic stability constant and standard free energy change indicates that inclusion complexes of the newly synthesized compounds are stable and their formation is thermodynamically allowed. Finally, the compounds and their inclusion complexes are screened for antibacterial, antioxidant and anthelmintic activities. It is found that inclusion complex formation increases the antibacterial, antioxidant and anthelmintic activities significantly as compared to naked compounds. The higher pharmacological activities have been explained in terms of enhanced solubility in the systemic circulation which makes them more available to specific tissues for better therapeutic efficacy.

Spectral and equilibrium studies on some new derivatives of 4-amino-5-phenyl-3-mercapto-1,2,4-triazole

4-Amino-5-phenyl-3-mercapto-1,2,4-triazole (APMT), 4-(4′-methoxy) benzylidineamino-5-phenyl-3-mercapto-1,2,4-triazole (PMBPMT), 4-benzylidineamino-5-phenyl-3-mcrcapto-1,2,4-triazole (BPMT), 4-(2′-hydroxy)benzylidineamino-5-phenyl-3-mercapto-1,2,4-triazole (HBPMT) and 4-amino-5-(4′-nitro)phenyl-3-mercapto-1,2,4-triazole (ANPMT) were synthesized and characterized by elemental analyses, IR, 1H NMR, 13C NMR, DEPT and Mass spectral studies. Proton dissociation constants of these compounds in 70% v/v dioxan water medium at 303 K. and 0.1 M (KNO3) ionic strength were measured. The order of the pKa corresponding to mercapto group follows the sequence : PMBPMT > BPMT > HBPMT > APMT > ANPMT.

Synthesis and characterization of trivalent chromium, manganese, iron and cobalt complexes with Schiff bases derived from 4-amino-5-mercapto-1,2,4- triazoles

Coordination complexes of Cr(III), Mn(III), Fe(III) and Co(III) with Schiff bases derived from 3-substituted phenyl-4-amino-5-mercapto-1,2,4-triazoles and anisaldehyde, veratraldehyde, salicylaldehyde, 2-hydroxyacetophenone have been prepared and characte