160290-95-9Relevant academic research and scientific papers
A potential photoaffinity probe for labelling the active site of aequorin: a photolabiile coelenterazine analogue with a trifluoromethyldiazirine group
Chen, Feng Qi,Zheng, Jing Ling,Hirano, Takashi,Niwa, Haruki,Ohmiya, Yoshihiro,Ohashi, Mamoru
, p. 2129 - 2134 (2007/10/02)
In order to clarify the active site of aequorin, we have succesfully synthesized a photolabile analogue of coelenterazine with a trifluoromethyl diazirine group as a photoaffinity probe.Our studies of the chemi- and bioluminescence of this novel analogue indicate that its behaviour is almost identical with that of natural coelenterazine in terms of luminescence characteristics.Therefore, the analogue with the photolabile diazirine should be a useful photoaffinity label for probing the detailed structure of aequorin.
Synthesis and Preliminary Chemi- and Bio-luminescence Studies of a Novel Photolabile Coelenterazine Analogue with a Trifluoromethyl Diazirine Group
Chen, Feng-Qi,Hirano, Takashi,Hashizume, Yoshinobu,Ohmiya, Yoshihiro,Ohashi, Mamoru
, p. 2405 - 2406 (2007/10/02)
A novel photolabile analogue of coelenterazine with a trifluoromethyl diazirine group is successfully synthesized for photoaffinity labelling of the active site of aequorin; preliminary studies on its chemi- and bio-luminescence demonstrate that the photo
