148058-41-7

Upstream product

• 148058-40-6 2-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)acetic acid 
• 37156-84-6 4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol 
• 168292-84-0 8-benzyl-6-(4-hydroxyphenyl)-2-<4-(3-trifluoromethyl(diazirin-3-yl))benzyl>-3,7-fihydroimidazo<1,2-a>pyrazin-3-one 
• 160290-93-7 4-(3-fluoromethyldiazirin-3-yl)phenylacetyl chloride 
• 160290-97-1 2-oxo-3-<4-(3-fluoromethyldiazirin-3-yl)phenyl>propanal 
• 160290-95-9 1-bromo-3-<4-(3-fluoromethyldiazirin-3-yl)phenyl>acetone 
• 160290-94-8 1-azo-3-<4-(3-fluoromethyldiazirin-3-yl)phenyl>acetone 
• 160290-96-0 2-oxo-3-<4-(3-fluoromethyldiazirin-3-yl)phenyl>propyl nitrate 

Relevant academic research and scientific papers

3-Benzyl-5-(4-hydroxyphenyl)-2-pyrazine, a Photoreactive Analogue of Coelenteramide. Synthesis and Photolysis

A photoreactive analogue of coelenteramide (light emitting species in aequorin bioluminescence) has been synthesized for photoaffinity labeling studies of aequorin.Photolysis of this compound in methanol gave a formal OH insertion product in 62percent yield without damage of the main skeleton of coelenteramide, indicating a potential use for mapping the coelenterazine binding site in aequorin.

A potential photoaffinity probe for labelling the active site of aequorin: a photolabiile coelenterazine analogue with a trifluoromethyldiazirine group

In order to clarify the active site of aequorin, we have succesfully synthesized a photolabile analogue of coelenterazine with a trifluoromethyl diazirine group as a photoaffinity probe.Our studies of the chemi- and bioluminescence of this novel analogue indicate that its behaviour is almost identical with that of natural coelenterazine in terms of luminescence characteristics.Therefore, the analogue with the photolabile diazirine should be a useful photoaffinity label for probing the detailed structure of aequorin.