160341-87-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-4-iodobutane is used as a precursor in the synthesis of various pharmaceuticals. Its reactivity and structural features enable the creation of a wide array of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-chlorophenyl)-4-iodobutane serves as a starting material for the development of new agrochemicals. Its chemical properties allow for the production of compounds that can be utilized in the agricultural industry for pest control, crop protection, and other related applications.
Used in Organic Synthesis:
1-(4-chlorophenyl)-4-iodobutane is employed as a versatile building block in organic synthesis. Its ability to undergo multiple chemical reactions makes it a valuable component in the construction of complex organic molecules for various applications, including the development of new materials, dyes, and other specialty chemicals.

Upstream product

• 19967-22-7 4-(p-chlorophenyl)-1-butanol 
• 3047-24-3 4-(p-chlorophenyl)-1-butene 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 108-90-7 chlorobenzene 

Downstream Products

• 160341-83-3 Methyl 1-[4-(4-chlorophenyl)butyl]cyclohex-3-enecarboxylate 

Relevant academic research and scientific papers

Electrophilic Iron Catalyst Paired with a Lithium Cation Enables Selective Functionalization of Non-Activated Aliphatic C?H Bonds via Metallocarbene Intermediates

Combining an electrophilic iron complex [Fe(Fpda)(THF)]2 (3) [Fpda=N,N′-bis(pentafluorophenyl)-o-phenylenediamide] with the pre-activation of α-alkyl-substituted α-diazoesters reagents by LiAl(ORF)4 [ORF=(OC(CF3)3] provides unprecedented access to selective iron-catalyzed intramolecular functionalization of strong alkyl C(sp3)?H bonds. Reactions occur at 25 °C via α-alkyl-metallocarbene intermediates, and with activity/selectivity levels similar to those of rhodium carboxylate catalysts. Mechanistic investigations reveal a crucial role of the lithium cation in the rate-determining formation of the electrophilic iron-carbene intermediate, which then proceeds by concerted insertion into the C?H bond.

One-pot synthesis of tetralin derivatives from 3-benzoylpropionic acids: Indium-catalyzed hydrosilylation of ketones and carboxylic acids and intramolecular cyclization

This reducing system was composed of a small amount (1 mol%) of In(OAc)3, Me2PhSiH, and I2 that effectively catalyzed the hydrosilylation of two different carbonyl groups, a ketone and a carboxylic acid found in 3-benzoylpropionic acids, followed by a subsequent intramolecular cyclization that led to the one-pot preparation of tetralin derivatives.

Iron-copper cooperative catalysis in the reactions of alkyl grignard reagents: Exchange reaction with alkenes and carbometalation of alkynes

Iron-copper cooperative catalysis is shown to be effective for an alkene-Grignard exchange reaction and alkylmagnesiation of alkynes. The Grignard exchange between terminal alkenes (RCH=CH2) and cyclopentylmagnesium bromide was catalyzed by FeCl3 (2.5 mol %) and CuBr (5 mol %) in combination with PBu3 (10 mol %) to give RCH2CH 2MgBr in high yields. 1-Alkyl Grignard reagents add to alkynes in the presence of a catalyst system consisting of Fe(acac)3, CuBr, PBu3, and N,N,N″,N″-tetramethylethylenediamine to give β-alkylvinyl Grignard reagents. The exchange reaction and carbometalation take place on iron, whereas copper assists with the exchange of organic groups between organoiron and organomagnesium species through transmetalation with these species. Sequential reactions consisting of the alkene-Grignard exchange and the alkylmagnesiation of alkynes were successfully conducted by adding an alkyne to a mixture of the first reaction. Isomerization of Grignard reagents from 2-alkyl to 1-alkyl catalyzed by Fe-Cu also is applicable as the first 1-alkyl Grignard formation step.