160357-94-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Acetylpiperidin-4-amine is used as a key intermediate in the synthesis of various drugs for the treatment of different diseases and conditions. Its role in the development of antiviral and antitumor drugs is particularly noteworthy, as it contributes to the creation of life-saving medications.
Used in Agrochemicals Industry:
1-Acetylpiperidin-4-amine is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness and selectivity of these compounds.
Used in Materials Science:
1-Acetylpiperidin-4-amine is used in the development of new materials with specific properties, such as improved stability or reactivity, by serving as a building block in the synthesis of novel organic compounds.

InChI:InChI=1/C7H14N2O/c1-6(10)9-4-2-7(8)3-5-9/h7H,2-5,8H2,1H3

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 283167-28-2 tert-butyl (1-acetylpiperidin-4-yl)carbamate 
• 135581-16-7 1-acetyl-4-piperidinone oxime 
• 32161-06-1 1-acetyl-4-piperidinone 
• 577778-36-0 1-(4-benzylamino-piperidin-1-yl)-ethanone 

Downstream Products

• 1056678-74-0 C₁₄H₁₇N₃O₅ 
• 1120313-08-7 C₂₁H₂₁N₃O₃S 
• 1120312-62-0 C₁₆H₂₄N₂O₃ 
• 1120312-71-1 C₂₂H₂₇N₃O₅S 
• 926304-02-1 C₂₁H₂₁N₃O₃S 
• 1431626-89-9 C₁₉H₂₀FN₅O 
• 1884246-71-2 6-((1-acetylpiperidin-4-yl)amino)pyrimidine-4-carboxylic acid 

Relevant academic research and scientific papers

Compounds and methods of use

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN

Disclosed herein are compounds and compositions having potency in the modulation of Myc family proteins. Such compounds and compositions can be used in the treatment of proliferative diseases, such as cancer, or in the treatment of disease where modulation of Myc family proteins is desired. Also disclosed herein are methods of using said compounds and compositions.

TRICYCLIC COMPOUNDS FOR USE IN TREATMENT OF PROLIFERATIVE DISORDERS

The present invention relates to compounds of Formula (I) as defined herein, and salts, hydrates and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to the use of compounds of Formula (I) in the treatment or prevention of PRMT5-mediated disorders, such as cancer.

BENZOPIPERIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND HEMOGLOBINOPATHIES

A compound of formula I: (I) wherein: n is 1 or 2; p is 0 or 1; R1a, R1b, R1c and R1d are independently selected from H, halo, C1-4 alkyl, C1-4 fluoroalkyl, C3-4 cycloalkyl, C1-4 alkyloxy, NH-C1-4 alkyl and cyano; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2e is H or Me; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (IIa), where R7a is selected from N-linked N-containing C5-7 heterocycyl and (A); or (ii) (IIb), where X is selected from CH2, N H and O, one of R8a and R8b is selected from CI and ethoxy and the other of R8a and R8b is H.

PYRROLOPYRIMIDINECARBOXAMIDES

The compounds of Formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of

SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are urea compounds, stereoisomer, or pharmaceutical acceptable salt thereof, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.

NK1 ANTAGONIST

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-meditated conditions.Formula (I)

4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.

5-HT4 agonists and antagonists

Compounds of formula I: are used as antagonists and partial agonists for the serotonin receptor 5-HT4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT4 receptor.