160357-94-8

Basic information

• Product Name: 1-Acetylpiperidin-4-amine
• Synonyms: 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE;1-ACETYLPIPERIDIN-4-AMINE;4-AMINO-1-ACETYL-PIPERIDINE;4-Amino-N-1-acetylpiperidine;1-ACETYL-4-AMINO-PIPERIDINE ;1-(4-Aminopiperidino)-1-ethanone;1-acetyl-4-piperidinamine(SALTDATA: HCl);1-(4-Aminopiperidin-1-yl)ethan-1-one, 1-Acetylpiperidin-4-amine
• CAS NO: 160357-94-8
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Product Categories: Amines;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 160357-94-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 273.642 °C at 760 mmHg
• Flash Point: 119.295 °C
• Appearance: /
• Density: 1.043 g/cm³
• Vapor Pressure: 0.00566mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.37±0.20(Predicted)
• CAS DataBase Reference: 1-Acetylpiperidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetylpiperidin-4-amine(160357-94-8)
• EPA Substance Registry System: 1-Acetylpiperidin-4-amine(160357-94-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• RIDADR: UN2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 160357-94-8(Hazardous Substances Data)

Usage

General Description

1-Acetylpiperidin-4-amine, also known as N-Acetyl-4-piperidinamine, is a chemical compound that is commonly used in the synthesis of pharmaceuticals and organic compounds. It is a derivative of piperidine and has a variety of applications in the pharmaceutical industry, particularly in the development of drugs for the treatment of various diseases and conditions. 1-Acetylpiperidin-4-amine has been shown to have potential as an intermediate in the synthesis of antiviral and antitumor drugs, and it has also been investigated for its potential as a building block for the synthesis of other organic compounds. Additionally, 1-Acetylpiperidin-4-amine may have potential uses in other industries such as agrochemicals and materials science.

InChI:InChI=1/C7H14N2O/c1-6(10)9-4-2-7(8)3-5-9/h7H,2-5,8H2,1H3

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 283167-28-2 tert-butyl (1-acetylpiperidin-4-yl)carbamate 
• 135581-16-7 1-acetyl-4-piperidinone oxime 
• 32161-06-1 1-acetyl-4-piperidinone 
• 577778-36-0 1-(4-benzylamino-piperidin-1-yl)-ethanone 

Downstream Products

• 223136-62-7 N-Acetyl-1-(3-(4-fluorophenoxy)propyl)-4-aminopiperidine 
• 1056678-74-0 C₁₄H₁₇N₃O₅ 
• 1431626-89-9 C₁₉H₂₀FN₅O 
• 1616392-22-3 GSK-3326595 
• 1884246-71-2 6-((1-acetylpiperidin-4-yl)amino)pyrimidine-4-carboxylic acid 
• 1257044-98-6 N-({4-[(1-acetylpiperidin-4-yl)amino]-3-nitrophenyl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 

Relevant articles and documents

Compounds and methods of use

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

TRICYCLIC COMPOUNDS FOR USE IN TREATMENT OF PROLIFERATIVE DISORDERS

The present invention relates to compounds of Formula (I) as defined herein, and salts, hydrates and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to the use of compounds of Formula (I) in the treatment or prevention of PRMT5-mediated disorders, such as cancer.

PYRROLOPYRIMIDINECARBOXAMIDES

The compounds of Formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of