16037-45-9

Upstream product

• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 65411-95-2 trans-1,2-dibromo-1,2-bis(trimethylsilyl)ethene 
• 78907-78-5 trans-3,4-Dibrom-3,4-bis(trimethylsilyl)-1-pyrazolin 

Downstream Products

• 92524-98-6 trimethyl(1-methylpyrazol-3-yl)silane 
• 92525-00-3 3,4-bis(trimethylsilyl)-1-methylpyrazole 
• 92525-15-0 1-methyl-5--3-(trimethylsilyl)pyrazole 
• 92525-18-3 1-methyl-3-pyrazole 

Relevant academic research and scientific papers

Microwave-assisted synthesis of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds to acetylene derivatives

Microwave-assisted preparation of a wide range of 5-ethoxycarbonylpyrazoles and 3-pyrazoles by 1,3-dipolar cycloaddition of diazo compound to acetylenes is described. All reactions were carried out using high throughput sequential technique.{A figure is p

Synthesis and Reactions of 3,4-Bis(trimethylsilyl)-1-pyrazolines

1,3-Dipolar cycloaddition of diazomethane to the trans-1,2-bis(trimethylsilyl)ethenes 1 a-c affords the trans-3,4-bis(trimethylsilyl)-1-pyrazolines 2 a-c.Thermolysis of 2 a-c yields stereospecifically the trans-1,3-bis(trimethylsilyl)propenes 7 b, c and d.The pyrazoline 2 c is dehalogenated with Zn to give 3(5),4-bis(trimethylsilyl)pyrazole (8).Reaction of 2 a with tetrachloro-o-benzoquinone and of 2 b and c with methanolic NaOH leads to dehydrosilylation and elimination of halogenotrimethylsilane, respectively, with formation of the pyrazoles 9 - 11. 10 and 11 can be desilylated by treatment with acid to yield 12 and 13, resp.