1604-45-1Relevant articles and documents
Convenient method for the kinetic resolution of β-aminoalcohols
Pelotier, Béatrice,Priem, Ghislaine,Macdonald, Simon J.F.,Anson, Mike S.,Upton, Richard J.,Campbell, Ian B.
, p. 9005 - 9007 (2007/10/03)
A variety of easily removable protecting groups were tested in the kinetic resolution of N-protected β-aminoalcohols using chiral catalysts derived from N-4′-pyridinyl-α-methyl proline. The trifluoroacetyl group was the most promising protecting group as it gave the highest selectivities with all alcohols tested and can easily be removed without loss of enantiomeric excess. This strategy constitutes a convenient method for the kinetic resolution of β-aminoalcohols.