213550-24-4

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1604-45-1 N-trifluoroacetyl-L-serine methyl ester 

Downstream Products

• 213550-25-5 (R)-3-DMTr-serinol 
• 213550-26-6 N-{(R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-2-(2-oxo-2H-pyridin-1-yl)-acetamide 
• 179472-03-8 N-{(R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 

Relevant academic research and scientific papers

Incorporation of serinol derived acyclic nucleoside analogues into oligonucleotides: Influence on duplex and triplex formation

Phosphoramidites 6a-c were readily prepared by an original route and used to incorporate serinol derived units I-III in oligonucleotides which, compared to their natural analogues, exhibited a decreased hybridization capacity for duplex and triplex format

siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS

There is provided inter alia a conjugate for inhibiting expression of a target gene in a cell, said conjugate comprising a nucleic acid portion and ligand portions, said nucleic acid portion comprising at least one duplex region that comprises at least a